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. 2021 Apr 22;11:8690. doi: 10.1038/s41598-021-88099-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anandamide (AEA) sensitizes MDRSA CI-M to methicillin and norfloxacin. (A) The survival of planktonic growing MDRSA CI-M after a 24 h incubation in a checkerboard assay of AEA with methicillin. A Anandamide; M Methicillin. (B) The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml methicillin (MET) and increasing concentrations of AEA. (C) The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml norfloxacin (NOR) and increasing concentrations of AEA. (D) The survival of planktonic growing MDRSA CI-M in the presence of increasing concentrations of AEA alone. (E) A kinetic study of the planktonic growth of MDRSA CI-M in the presence of increasing concentrations of AEA. *p < 0.05; **p < 0.01.