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. 2021 Apr 22;12:2388. doi: 10.1038/s41467-021-22571-9

Fig. 7. BMAL1 chromatin binding to selected targets, their transcript, and protein levels in human omental adipocyte precursors from non-obese and obese subjects.

Fig. 7

We selected from Fig. 6 some BMAL1 targets for their relevance in the pathogenesis of obesity and performed, for each of them, conventional ChIP analyses, and measurements of mRNA and protein levels in OAPs. A FLOT1 Flotillin1, B MMP2 Matrix Metalloproteinase 2, C NCOR2 Nuclear Repressor Corepressor 2, D LOXL2 Lysyl Oxidase Homolog 2, E PAI1 Plasminogen Activator Inhibitor-1, F MLL1 Histone-lysine N-methyltransferase 2A, G GPX1 glutathione peroxidase 1. ChIP data are expressed as fold enrichment over IgG, mRNAs as relative abundance (RA), and protein levels in pg or μU/μg total proteins. Histograms represent the mean ± SEM for 4 (ChIP) or 8 (mRNA and protein) patients per group. p < 0.05, **p < 0.01, ***p < 0.001 by unpaired two-tailed t-test. See also Supplementary Fig. 4.