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. 2021 Apr 22;11:8731. doi: 10.1038/s41598-021-87917-1

Table 1.

Demographic data and comorbid conditions in patients with different disease severities.

Feature Disease severity P1 P2***
Mild/moderate (N = 33) Severe (N = 139) Critical (N = 28)
Demographic data
Sex (female) 15 (45.5) 55 (39.6) 12 (42.9) 0.569* 0.807
Age (years) 54.87 ± 18.35 57.80 ± 14.80 66.71 ± 16.61 0.149** 0.009
Comorbid conditions
DM 6 (18.2) 43 (30.9) 12 (42.9) 0.093* 0.111
IHD 5 (15.2) 22 (15.8) 7 (25.0) 0.757* 0.476
Hypertension 7 (21.2) 40 (28.8) 10 (35.7) 0.310* 0.454
Asthma 0 (0.0) 5 (3.6) 0 (0.0) 0.314* 0.325
Autoimmune disease 1 (3.0) 3 (2.2) 1 (3.6)  > 0.999* 0.888
CKD 0 (0.0) 2 (1.4) 1 (3.6) 0.438* 0.517
Transplantation 1 (3.0) 0 (0.0) 0 (0.0) 0.024* 0.079
COPD 2 (6.1) 13 (9.4) 1 (3.6) 0.653* 0.721
Cerebrovascular disease 0 (0.0) 3 (2.2) 0 (0.0) 0.438* 0.513
CNS disease 0 (0.0) 2 (1.4) 0 (0.0) 0.528* 0.642
Hepatitis 1 (3.0) 0 (0.0) 0 (0.0) 0.024* 0.079
Hypothyroidism 0 (0.0) 2 (1.4) 1 (3.6) 0.438* 0.517
Malignancy 0 (0.0) 3 (2.2) 5 (17.9) 0.199*  < 0.001
Smoking 5 (15.2) 14 (10.1) 4 (14.3) 0.822* 0.544
Addiction 0 (0.0) 5 (3.6) 0 (0.0) 0.593* 0.325
Alcohol use 0 (0.0) 1 (0.7) 0 (0.0)  > 0.999* 0.802
Clinical characteristics of COVID-19
Symptomatic period (days) 6.00 ± 6.50 7.09 ± 4.31 6.81 ± 3.54 0.294** 0.555
Hospital stay (days) 6.48 ± 3.94 7.27 ± 3.39 7.56 ± 4.74 0.249** 0.484

DM diabetes mellitus, IHD ischemic heart disease, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, CNS central nervous system.

P1: Comparison between mild/moderate and severe/critical groups.

P2: Comparison between mild/moderate, severe, and critical groups.

Bold values are statistically significant (P < 0.05).

*Chi-square or Fisher’s exact test.

**Mann–Whitney test.

***Kruskal–Wallis test.