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. 2021 Apr 22;11:8731. doi: 10.1038/s41598-021-87917-1

Table 3.

Paraclinical data in patients with different disease severities.

Feature Disease severity P1 P2***
Mild/moderate (N = 33) Severe (N = 139) Critical (N = 28)
Laboratory findings
Lymphopenia 24 (75.0) 99 (76.2) 19 (70.4) 0.985* 0.818
VBG pH 7.42 ± 0.05 7.41 ± 0.05 7.10 ± 1.29 0.572** 0.030
VBG pO2 (mmHg) 36.27 ± 9.11 32.21 ± 9.48 31.85 ± 8.51 0.037** 0.021
VBG pCO2 (mmHg) 39.01 ± 6.81 40.33 ± 7.84 35.12 ± 7.92 0.824** 0.112
VBG pHCO3 (mmHg) 25.86 ± 4.05 25.94 ± 5.05 23.14 ± 4.32 0.705** 0.054
AST (IU/L) 57.92 ± 76.53 48.55 ± 74.94 54.42 ± 31.50 0.470** 0.031
ALT (IU/L) 59.64 ± 87.35 50.94 ± 77.99 49.78 ± 60.37 0.210** 0.384
LDH (U/L) 560.20 ± 200.34 660.74 ± 434.76 897.70 ± 287.47 0.310** 0.137
CRP (mg/L) 51.64 ± 52.07 86.22 ± 62.33 167.59 ± 146.86 0.003** 0.001
Chest CT findings
Consolidation None 8 (24.2) 36 (25.9) 5 (17.9) 0.009* 0.002
1 lobe 1 (3.0) 3 (2.2) 0 (0.0)
2 lobes 21 (63.6) 55 (39.6) 6 (21.4)
3 lobes 0 (0.0) 1 (0.7) 2 (7.1)
4 lobes 3 (9.1) 44 (31.7) 15 (53.6)
GGO None 7 (21.2) 32 (23.0) 9 (32.1)  < 0.001*  < 0.001
1 lobe 3 (9.1) 0 (0.0) 0 (0.0)
2 lobes 13 (39.4) 25 (18.0) 6 (3.6)
3 lobes 0 (0.0) 4 (2.9) 0 (0.0)
4 lobes 10 (30.3) 78 (56.1) 18 (64.3)
PE 1 (3.0) 8 (5.8) 4 (14.3) 0.376* 0.168
Bronchiectasis 0 (0.0) 1 (0.7) 0 (0.0) 0.656* 0.802

VBG venous blood gas, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, CRP C-reactive protein, CT computed tomography, GGO ground-glass opacity, PE pleural effusion.

P1: Comparison between mild/moderate and severe/critical groups.

P2: Comparison between mild/moderate, severe, and critical groups.

Bold values are statistically significant (P < 0.05).

*Chi-square or Fisher’s exact test.

**Mann–Whitney test.

***Kruskal–Wallis test.