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. 2021 Apr 22;7:40. doi: 10.1038/s41522-021-00211-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Organization of the anisomycin biosynthesis operon and impact of SsoPox W263I on the anisomycin biosynthetic pathway. In operon representation, arrows indicate the direction of transcription. Pathway and nomenclature are from Zheng et al.⁴¹. Proteins (dashed line boxes) and metabolites (full-line boxes) normalized scaled intensities (NSI) are represented as the mean and standard deviations (metabolomic: n = 3 biological replicates, proteomic: n = 8, 4 biological replicates × 2 technical replicates). *P value <0.05, **P value <0.01, ***P value <0.001 according to Student’s t test. FC fold change. b Correlation multi-omics network of the protein AniQ (square) and metabolites (hexagons) involved in the production of anisomycin. Metabolites significantly impacted by SsoPox W263I are positively (green) or negatively (red) connected with AniQ.