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. 2021 Apr 22;11:8800. doi: 10.1038/s41598-021-88003-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary figure: Chromatin accessibility along maturation is affected by Scrt1. In the present study we investigated the chromatin accessibility along the post-natal pancreatic islet maturation process. (a) SCRT1 motif is enriched in ACS that are closing upon maturation. We found that Scrt1 is a direct target of REST and that the Scrt1 motif is present in TSS/proximal sites as well as distal sites. The inhibition of Scrt1 lead to increased proliferation and has additional effects on other processes such as specialization. (b) In an in vitro reprogramming system, Scrt1 expression raises after PNM infection and is anti-correlated with REST levels.