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. 2021 Apr 22;11:8766. doi: 10.1038/s41598-021-88090-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased expression of the postsynaptic marker PSD-95 in the hippocampus of mice overexpressing the S49P-Syracuse mutation. Representative western blots of hippocampal extracts from four-five different animals aged 64 weeks overexpressing either wild-type (WT-Tg) or S49P-Syracuse mutant neuroserpin (Syr-Tg). Non-transgenic, wild-type mice (non-Tg) were used as controls. Extracts were separated by SDS-PAGE and analyzed with antibodies against PSD-95 (post-synapse) and synaptophysin, SNAP25 and synapsin-I (pre-synapse). Band intensity was normalized to β-actin expression. Relative expression is presented (AU, arbitrary units), wild-type was set to 1 (mean + /− SD; n = 4–5; for PSD-95: non-Tg vs. Syr-Tg: p = 0.0003; non-Tg vs. WT-Tg: p = 0.1890; WT-Tg vs. Syr-Tg: p = 0.0118; p = 0.3547 for synaptophysin; p = 0.8795 for synapsin-I; p = 0.4594 for SNAP25). Western blot membranes have been cropped, full-length blots are presented in Supplementary Fig. S3.