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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Hepatology. 2021 May 14;73(6):2251–2265. doi: 10.1002/hep.31604

Figure 2. Hepatocyte-specific expression of human HNF4α is sufficient to prevent HFCF diet-induced hepatosteatosis.

Figure 2.

C57BL/6J mice were injected i.v. with AAV8-ALB-Null or AAV8-ALB-hHNF4α and then fed an HFCF diet for 20 weeks (n=8 per group). (A) Hepatic TG (left panel) and FFA (right panel) levels. (B) Hepatic fatty acid composition was analyzed by GC-MS. (C) Liver sections were stained by Oil Red O (top panel) or H&E (lower panel). (D) Hepatic mRNA levels (left panel) or protein levels (right panel). (E) Hepatic TGH activity. (F) FAO was analyzed using isolated hepatocytes. *P<0.05, **P<0.01