Table 2.
Distribution of genetic variants in glutathione-related genes in Hg exposed and non-exposed groups.
| Gene | SNP | Genotype/allele | Exposed | Non-exposed | HWE P value |
P valued | P valuee | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 160 | N = 121 | |||||||||
| N (%) | N (%) | |||||||||
| GCLC | rs1555903 | TT | 66 (41.3) | 48 (39.7) | 0.96a | 0.96 | 0.81 | |||
| TC | 73 (45.6) | 56 (46.3) | 0.94b | 1.0 | ||||||
| CC | 21 (13.1) | 17 (14.0) | 0.94c | 0.85 | ||||||
| T | 205 (64.0) | 152 (62.8) | ||||||||
| C | 115 (36.0) | 90 (37.2) | 0.78 | 1.05 (0.75–1.49) | ||||||
| GCLM | rs41303970 | CC | 63 (39.4) | 72 (59.5) | 0.31a | 0.0015 | 0.0009 | 0.44 (0.27–0.72) | ||
| CT | 80 (50.0) | 45 (37.2) | 0.45b | 0.039 | 1.69 (1.04–2.73) | |||||
| TT | 17 (10.6) | 4 (3.3) | 0.32c | 0.026 | 3.48 (1.13–10.6) | |||||
| C | 206 (64.3) | 189 (78.0) | ||||||||
| T | 114 (35.7) | 53 (22.0) | 0.0004 | 1.97 (1.35–2.89) | ||||||
| GSS | rs3761144 | CC | 64 (40.0) | 53 (43.8) | 0.047a | 0.43 | ||||
| CG | 64 (40.0) | 51 (42.2) | 0.49b | |||||||
| GG | 32 (20.0) | 17 (14.0) | 0.036c | |||||||
| C | 192 (60.0) | 157 (64.8) | ||||||||
| G | 128 (40.0) | 85 (35.2) | 0.23 | 1.23 (0.87–1.74) | ||||||
| GSTA1 | rs3957356 | CC | 71 (44.4) | 45 (40.2) | 0.71a | 0.18 | ||||
| CT | 69 (43.1) | 59 (52.7) | 0.07b | |||||||
| TT | 20 (12.5) | 8 (7.1) | 0.45c | |||||||
| C | 211 (66.0) | 149 (66.5) | ||||||||
| T | 109 (34.0) | 75 (33.5) | 0.92 | 1.03 (0.71–1.47) | ||||||
| GSTP1 | rs4147581 | CC | 76 (47.5) | 43 (35.5) | 0.62a | 0.015 | 0.042 | 1.64 (1.01–2.66) | ||
| CG | 71 (44.4) | 55 (45.4) | 0.56b | 0.89 | ||||||
| GG | 13 (8.1) | 23 (19.1) | 0.84c | 0.012 | 0.37 (0.18–0.77) | |||||
| C | 223 (69.7) | 141 (58.3) | ||||||||
| G | 97 (30.3) | 101 (41.7) | 0.005 | 0.60 (0.43–0.86) | ||||||
Statistically significant association are shown in bold (P value < 0.05).
The statistical significance was determined using Pearson’s Chi-square test with P value simulated from 2000 permutations.
P value for Hardy–Weinberg equilibrium in exposeda and non-exposedb groups, and all samplesc.
dP value for allele and genotype associations.
eP value for each genotype versus the other two genotypes.