Table 3.

Association of genetic variants in glutathione-related genes with Hg levels in blood and urine.

Gene	SNP	N	Blood-Hg (µg Hg/L)			Urine-Hg (µg Hg/g creatinine)
			β	P valuea	P valueb	β	P valuea	P valueb
GCLC	rs1555903	281	− 0.042	0.07	0.03	− 0.008	0.76	0.74
GCLM	rs41303970	281	− 0.012	0.65	0.56	0.062	0.047	0.009
GSS	rs3761144	281	0.014	0.51	0.55	− 0.002	0.94	1.0
GSTA1	rs3957356	272	0.032	0.19	0.74	− 0.012	0.67	0.32
GSTP1	rs4147581	281	0.004	0.86	0.88	− 0.003	0.92	1.0

Statistically significant association are shown in bold (P value < 0.05).

Each SNP was examined using multivariable linear regression models assuming additive models of inheritance adjusted by exposure status, age, sex, eGFR, and hair-Hg levels (µg Hg/g hair).

^aP value from a generalized linear model.

^bEmpirical P value determined based on 5000 permutations from a generalized linear model.