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. 2021 Apr 22;11:8788. doi: 10.1038/s41598-021-88200-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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5-choice-serial-reaction-time task (5-CSRTT) performance. Results of attention challenge (reduction of stimulus duration, SD, from 2 to 1 s; left) and impulsivity challenge (increase of inter-trial-interval, ITI, from 5 to 9 s; right) across six key parameters of the 5-CSRTT. (A) Accuracy as primary measure of attention, (B) relative omissions as a measure of task engagement and attentiveness, (C) relative premature responses as primary measure of waiting impulsivity, (D) relative perseverative responses, (E) total number of correct responses (earned rewards), and (F) latency to collect the reward as a compound proxy for locomotor drive and motivation. Grey statistical indicators relate to RM-ANOVA, with asterisks on horizontal lines indicating effect of challenge, and asterisks on vertical lines referring to an effect of group; no significant challenge-group interactions were found. The legend indicates the colour-code and size of each group. See Supplementary Table 4 for all related statistics. n.s., P > 0.1, *P < 0.05, **P < 0.01 ***P < 0.001. Error bars, s.e.m.