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. 2021 Apr 22;11:8708. doi: 10.1038/s41598-021-88229-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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hDCIS.01 xenografts enriched for CCR2 expression show increased CCL2, phospho-SMAD3 and phospho-p42/44MAPK expression. hDCIS.01 xenografts were immunostained for expression of: (A) CCL2, (B) CCR2, (C) phospho-SMAD3 or (D) phospho-p42/44MAPK. Normal adjacent tissues were from parental lesions. Normal adjacent n = 12, parental n = 14, CCR2+ n = 12. Expression was quantified by Image J. Statistical analysis was performed using One Way ANOVA with Bonferroni post-hoc comparison. Whisker box plots are shown. Whiskers indicate min and max values. Box indicates upper and lower quartile range. Line indicates median. Statistical significance was determined by p < 0.05. Scale bar = 200 microns.