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. 2021 Apr 9;12:648554. doi: 10.3389/fimmu.2021.648554

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Copyright © 2021 Versey, da Cruz Nizer, Russell, Zigic, DeZeeuw, Marek, Overhage and Cassol

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting bacteria-innate immune interactions to restore healing in chronic wounds. Standard therapies such as debridement, NPWT, antiseptics, and antibiotics have been shown to reduce bacterial bioburden in the wound bed, but they do not always restore healing processes. New therapeutics that have both antimicrobial and immunomodulatory properties may be able to overcome the limitations of more traditional treatments. Here, we show novel therapeutics that target these interactions that can be used in early and late stages of healing to restore tissue homeostasis. LPS, lipopolysaccharide; EPS, extracellular polymeric substance; PGA, peptidoglycan; AMP, antimicrobial peptide; mAb, monoclonal antibody; miRNA, microRNA. Created with BioRender.com.