Table 1.
List of proteins targeted by follistatin.
| Model System | Protein | Change | Reference |
|---|---|---|---|
| Mouse embryonic fibroblast (MEF) cultures in adipogenic differentiation medium; WT vs. Fst KO |
UCP1 | ↓ | (144) |
| PRDM16 | ↓ | (144) | |
| aP2 | ↓ | (144) | |
| PPARγ | ↓ | (144) | |
| PGC-1α | ↓ | (144) | |
| Cyt C | ↓ | (144) | |
| Interscapular brown adipose tissue (BAT); WT vs. Fst-Tg | UCP1 | ↑ | (147) |
| UCP2 | ↑ | (147) | |
| UCP3 | ↑ | (147) | |
| PRDM16 | ↑ | (147) | |
| PGC-1α | ↑ | (147) | |
| AdipoQ | ↑ | (147) | |
| Myf5 | ↑ | (147) | |
| pSmad3 | ↓ | (147) | |
| Smad3 | ↓ | (147) | |
| ActRIIB | ↓ | (147) | |
| Epididymal and subcutaneous adipose tissue; WT vs. Fst-Tg | UCP1 | ↑ | (147) |
| UCP2 | ↑ | (147) | |
| UCP3 | ↑ | (147) | |
| PRDM16 | ↑ | (147) | |
| PGC1α | ↑ | (147) | |
| BMP7 | ↑ | (147) | |
| Glut4 | ↑ | (147) | |
| CD137 | ↑ | (147) | |
| pp38 MAPK | ↑ | (147) | |
| pERK1/2 | ↑ | (147) | |
| pSmad3 | ↓ | (147) | |
| Smad3 | ↓ | (147) | |
| ActRIIB | ↓ | (147) | |
| AdipoQ | ↑ | (148) | |
| FGF21 | ↑ | (148) | |
| pAMPK | ↑ | (148) | |
| Differentiating 3T3-L1 cells treated with recombinant FST (rFST); Control vs. rFST | UCP1 | ↑ | (147) |
| CD137 | ↑ | (147) | |
| pp38 MAPK | ↑ | (147) | |
| pERK1/2 | ↑ | (147) | |
| AdipoQ | ↑ | (148) | |
| AdipoR1 | ↑ | (148) | |
| FGF21 | ↑ | (148) | |
| pAMPK | ↑ | (148) | |
| PGC-1α | ↑ | (148) | |
| SirT1 | ↑ | (148) | |
| Mouse brown adipose tissue (BAT) cells treated with rFST: Con vs. rFST | UCP1 | ↑ | (147) |
| Eva1 | ↑ | (147) | |
| Myf5 | ↑ | (147) | |
| Fst overexpressing stable 3T3-L1 (3T3-L1 Fst) cells; 3T3-L1-Fst vs. 3T3-L1 | UCP1 | ↑ | (148) |
| CD137 | ↑ | (148) | |
| p38 MAPK | ↑ | (148) | |
| pERK1/2 | ↑ | (148) | |
| COX-IV | ↑ | (148) | |
| SirT1 | ↑ | (148) | |
| SirT3 | ↑ | (148) | |
| AdipoQ | ↑ | (148) |