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. 2021 Apr 9;12:659597. doi: 10.3389/fphar.2021.659597

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Copyright © 2021 Zhou, Li, Wang, Jiang, Li, Wang, Wang, Ma and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sodium butyrate (NaB) normalizes the expression of aggrecan, Bax, LC3-II, and p62 in articular cartilage 60 days after the operation. (A) Immunostaining of aggrecan, Bax, LC3-II, and p62 after 60 days postoperation. (B–E) The quantification of cells with positive staining for aggrecan. (B), Bax (C), LC3-II (D), and p62 (E); scale bar, 100 μm, n = 10 per group. The data are presented as the mean ± S.D. Significant differences between the different groups were determined by one-way ANOVA; *p < 0.05, **p < 0.01.