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Sodium butyrate (NaB) alleviated interleukin (IL)-1β-induced extracellular matrix (ECM) degradation and inflammation in chondrocytes. Chondrocyte treatments were the same as above (A,B) Chondrocyte expression of collagen II, aggrecan, matrix metalloproteinase (MMP)-3, and cyclooxygenase (COX)-2 proteins detected by western blotting. The data are presented as the mean ± S.D. Significant differences between groups were determined by one-way ANOVA; *p < 0.05, **p < 0.01; n = 3.
