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. 2021 Apr 9;12:616050. doi: 10.3389/fmicb.2021.616050

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Copyright © 2021 Bednarz, Millan-Oropeza, Kotowska, Świat, Quispe Haro, Henry and Pawlik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap representation of mean abundances of proteins in S. coelicolor A3(2) M145, ΔcpkO and ΔcpkN strain. (A) Proteins from specialized metabolite biosynthetic clusters; ECR, expression correlated with RED. (B) Proteins associated with primary metabolism. (C) Proteins related to stress response and others; SHC, supercoiling-hypersensitive cluster. The method of quantification of each protein is indicated in colors on the left of the heatmap for extracted ion chromatogram (black), spectral count (orange) or peak count (cyan).