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. 2021 Apr 9;12:661911. doi: 10.3389/fimmu.2021.661911

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Copyright © 2021 Zhan, Li, Han, Wang, Zhao, Tu, Shi and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow chart of biopsies inclusion and exclusions for the study. We collected 312 kidney biopsy and selected 198 biopsies with an original diagnose of rejection and 114 subjects without rejection. 20 biopsies were redefined as CAAMR and 8 biopsies were defined as CAMR by a central pathologist. In 114 subjects without rejection, 12 patients diagnosed with non-specific lesions or mild drug-induced injuries were defined as Control. We excluded 1 subject with incomplete FFPE slides and 5 subjects with incomplete central pathology data. TCMR, T cell-mediated rejection; ABMR, antibody-mediated rejection; FFPE, formalin-fixed paraffin-embedded.