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. 2021 Apr 9;12:639009. doi: 10.3389/fphar.2021.639009

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Copyright © 2021 Huang, Hu, Shao, Wu, Zhang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of drug treatment on inflammatory cytokine secretion and oxidative defense in CIA-induced rats. Sprague-Dawley rats were induced by CIA for 14 days and subjected to daily drug administration at various doses for 20 consecutive days. (A) ELISA detection of the serum content of TNF-α, IL-1β, IL-6, and IL-10. (B) Biochemical detection of the content of MDA, SOD, and NO in the serum and synovial tissues. All data are expressed as the mean ± standard deviation (n = 3). *p < 0.05. Low, medium, and high doses of COR and PAE were administered, and dose response was analyzed. CIA: collagen-induced arthritis; COR: Cornus officinalis; PAE: Paeonia lactiflora; PF: paeoniflorin; UA: ursolic acid; DEX: dexamethasone; MDA: malondialdehyde; SOD: superoxide dismutase; NO: nitric oxide.