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. 2021 Apr 9;12:639009. doi: 10.3389/fphar.2021.639009

FIGURE 4.

FIGURE 4

Effect of drug treatment on the expression of proteins associated with apoptosis in CIA-induced rats. Sprague-Dawley rats were induced by CIA for 14 days and subjected to daily drug administration at various doses for 20 consecutive days. Western blot detection and quantification of the expression of apoptosis-related proteins (Bax, Bcl-2, cleaved caspase-3, and cytochrome-c) in synovial tissues. All protein expression was normalized to that of GAPDH as a housekeeping control. All data are expressed as the mean ± standard deviation (n = 3). *p < 0.05. Low, medium, and high doses of COR and PAE were administered, and dose response was analyzed. CIA: collagen-induced arthritis; COR: Cornus officinalis; PAE: Paeonia lactiflora; PF: paeoniflorin; UA: ursolic acid; DEX: dexamethasone; GAPDH: glyceraldehyde 3-phosphate dehydrogenase.