TABLE 1.
Evaluation of arthritic score in CIA-induced rats (n = 3). Arthritic score was assessed using the following scale: 0, no redness or swelling; 1, redness and swelling at the toe joints; 2, redness and swelling at the toes and toe joints; 3, redness and swelling in all areas below the ankle; 4, redness and swelling at in all areas below the ankle, including the ankle joint. COR: Cornus officinalis; PAE: Paeonia lactiflora Pall.; PF: paeoniflorin; UA: ursolic acid; DEX: dexamethasone.
| Day 0 | Day 4 | Day 7 | Day 12 | Day 14 | Day 24 | Day 32 | Day 34 | ||
|---|---|---|---|---|---|---|---|---|---|
| Control | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| CIA + CIA | 0 ± 0 | 3 ± 0 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 4 ± 0 | 4 ± 0 | 3 ± 0 | |
| COR (3.36 mg/kg/d) | 0 ± 0 | 3 ± 0 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 3.33 ± 0.58 | 2.33 ± 0.58 | 2 ± 0 | |
| PAE (6.27 mg/kg/d) | 0 ± 0 | 2.67 ± 0.58 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 3 ± 0 | 3 ± 0 | 2 ± 1 | |
| COR + PAE | 0 ± 0 | 2.67 ± 1.15 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 3.67 ± 0.58 | 2.67 ± 0.58 | 1.67 ± 0.58 | |
| PF (7.5 mg/kg/d) | 0 ± 0 | 3.33 ± 0.58 | 3.33 ± 0.58 | 4 ± 0 | 4 ± 0 | 3 ± 1 | 2 ± 1 | 1.33 ± 0.58 | |
| UA (25 mg/kg/d) | 0 ± 0 | 2 ± 0 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 3.33 ± 0.58 | 2 ± 0 | 1.33 ± 1.15 | |
| DEX (0.5 mg/kg/d) | 0 ± 0 | 2.67 ± 0.58 | 2.67 ± 0.58 | 4 ± 0 | 4 ± 0 | 2.33 ± 0.58 | 2.67 ± 0.58 | 0.33 ± 0.58 |