Table 3.
Acid–base parameters, hemofiltration settings, gas exchange and respiratory/ventilation parameters
| Parameter | 0 h (at switch) | 24 h (after switch) | p |
|---|---|---|---|
| N = 42 | N = 40 | ||
| Acid–base parameters | |||
| Bicarbonate, mmol/l | 27.7 (26.9–28.9) | 25.8 (24.6–27.7) | 0.000* |
| Base excess, mmol/l | 4.0 (3.1–5.1) | 1.8 (0.2–3.4) | 0.000* |
| pH | 7.42 (7.38–7.47) | 7.43 (7.37–7.46) | 0.311 |
| Lactate, mg/dl | 12.0 (7.3–14.0) | 12.0 (8.0–15.0) | 0.728 |
| Haemofiltration settings | |||
| Pre-dilution pre-blood pump fluid (Prismocitrate™), ml/h | 1200 (1200–1300) | 1,273 (1200–1300) | 0.569 |
| Substitution rate, ml/h | 800 (600–1000) | 800 (500–1000) | 0.943 |
| Fluid removal, ml/h | 100 (100–188) | 100 (100–150) | 0.543 |
| Blood flow, ml/min | 120 (125–130) | 120 (120–130) | 0.884 |
| Filtration fraction, % | 33 (30–36) | 33 (30–35) | 0.799 |
| Temperature, °C | 41.0 (40.0–43.0) | 41.0 (39.8–43.0) | 0.863 |
| Citrate dose, mmol/l | 3.0 (3.0–3.2) | 3.0 (3.0–3.2) | 0.127 |
| Ionized serum calcium, mmol/l | 1.09 (1.03–1.15) | 1.06 (1.00–1.12) | 0.170 |
| Calcium dose, mmol/h | 2.45 (2.10–2.88) | 2.65 (2.28–3.20) | 0.196 |
| Calcium substitution, % | 90 (85–105) | 100 (88–111) | 0.000* |
| Post-filter calcium, mmol/l | 0.41 (0.37–0.43) | 0.37 (0.36–0.40) | 0.006* |
| Gas exchange and respiratory/ventilation parameters | |||
| PaCO2, mmHg | 43.2 (39.7–47.5) | 39.6 (36.8–46.1) | 0.678 |
| PaO2, mmHg | 82.9 (70.1–95.7) | 84.2 (71.4–97.2) | 0.691 |
| Peripheral arterial oxygen saturation, % | 97.0 (93.7–98.3) | 96.8 (95.5–98.3) | 0.767 |
| PaO2/FiO2 ratio, mmHg | 227 (131–298) | 213 (136–328) | 0.834 |
| Ventilator parameters | N = 25 | N = 23 | |
| Respiratory rate, breaths/min | 17 (14–20) | 17 (15–20) | 0.971 |
| FiO2 | 0.35 (0.30–0.50) | 0.35 (0.30–0.53) | 0.861 |
| Tidal volume, mL/kg PBWa | 6.3 (5.8–6.9) | 6.5 (5.9–7.8) | 0.511 |
| Set positive end-expiratory pressure, cmH2O | 8 (8–10) | 8 (8–10) | 0.733 |
| Peak pressure, cmH2O | 19 (16–21) | 18 (16–21) | 0.529 |
| Driving pressure, cmH2O | 10 (7–12) | 9 (8–12) | 0.510 |
| Minute ventilation, mL/kg PBWa/min | 105 (85–123) | 111 (85–135) | 0.511 |
| Non-invasive ventilation parameters | N = 17 | N = 17 | |
| FiO2 | 0.50 (0.23–0.68) | 0.40 (0.21–0.49) | 0.177 |
| Respiratory rate, breaths/min | 16 (15–18) | 20 (13–24) | 0.404 |
Data reported as median (IQR), unless otherwise specified
aPBW predicted body weight