Fig. 2.

Possible silent hypoxia associated factors involved in COVID-19. Silent Hypoxia has been associated with several COVID-19 related symptoms. The condition can result in overexpression of ACE-2 receptors thereby increasing the risk of damage through COVID-19 infection. Besides, the condition can further contribute to the mechanism of “cytokine storm” by recruiting different mediators of inflammation. Moreover, silent hypoxia can cause serious endothelial damage through NF-kB transcription factor activation. Silent hypoxia can also signal a different immune-metabolism pathway and cause secondary organ damage. All these factors lead to the critical condition of patients along with an increased mortality rate among COVID-19 patients