Table 2.

The binding affinity of the ligands against native and mutant SARS-CoV-2 RdRp structures.

S.No	Protein	Ligands	Binding Affinity (kcal/mol)
(A)
1	Native RdRp	134502628	−7.5
2	Native RdRp	58527341	−6.3
3	Native RdRp	145074552	−6
4	Native RdRp	145074438	−6
5	Native RdRp	137648734	−5.5
6	Native RdRp	70649275	−5.3
7	Native RdRp	44468492	−5.1
8	Native RdRp	Remdesvir	−4.5
(B)
1	RdRp with P323L	134502628	−7.4
2	RdRp with P323L	70649275	−6.6
3	RdRp with P323L	137648734	−6.3
4	RdRp with P323L	145074552	−6.1
5	RdRp with P323L	Remdesvir	−5.6
6	RdRp with P323L	145074438	−5.5
7	RdRp with P323L	44468492	−5.3
8	RdRp with P323L	58527341	−4.2

(A) Against native RdRp, (B) against mutant RdRp.