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. 2021 Apr 9;12:645688. doi: 10.3389/fgene.2021.645688

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Copyright © 2021 Sepúlveda, Grignard, Curry, Mahey, Bastiaens, Tiono, Okebe, Coulibaly, Gonçalves, Affara, Ouédraogo, Bougouma, Sanou, Nébié, Lanke, Sirima, Dicko, d’Alessandro, Clark, Campino, Chen, Eziefula, Gosling, Bousema and Drakeley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic association analysis between log-Hb7 and each SNP adjusting or not for parasitemia at day 0 (A,B, respectively). Statistical significance was determined by the maximum of −log₁₀ (p-value) associated with the log-likelihood ratio tests when testing different genetic effects of each SNP in a linear regression model adjusting for age, gender, parasitemia at screening, and log-Hb0. The threshold for statistical significance was determined to ensure a false discovery rate (FDR) of 5%.