TABLE 3.
Estimation of the joint genetic models M1 (excluding data from BF2) and M2 (based on the whole data set) for the association between log-Hb7 and the best G6PD SNP adjusting or not for parasitemia at day 0 where the alleles A and B denote the reference and alternative alleles shown in Table 2.
| Model M1 |
Model M2 |
|||
| Predictor | Estimate (SE) | P-value | Estimate (SE) | P-value |
| Intercept | 1.021 (0.068) | <0.001 | 1.020 (0.066) | <0.001 |
| Study | ||||
| BF1 (reference) | – | – | – | – |
| BF2 | NA (NA) | NA | −0.015 (0.021) | 0.463 |
| GAM | −0.019 (0.019) | 0.327 | −0.014 (0.019) | 0.442 |
| KEN | 0.047 (0.011) | <0.001 | 0.047 (0.011) | <0.001 |
| MAL | −0.018 (0.033) | 0.577 | −0.004 (0.029) | 0.903 |
| UGD | 0.015 (0.009) | 0.100 | 0.012 (0.009) | 0.159 |
| Age (per year) | 0.005 (0.001) | <0.001 | 0.004 (0.001) | <0.001 |
| PQ dose (mg/kg) | ||||
| 0 | – | – | – | – |
| 0.10-0.40 | −0.007 (0.008) | 0.399 | −0.007 (0.008) | 0.328 |
| 0.41-0.75 | −0.016 (0.012) | 0.175 | −0.017 (0.012) | 0.159 |
| Gender | ||||
| Female (reference) | – | – | – | – |
| Male | −0.010 (0.009) | 0.261 | −0.012 (0.009) | 0.193 |
| log-Hb0 | 0.561 (0.029) | <0.001 | 0.565 (0.027) | <0.001 |
| Parasitemia (x 100,000) | −0.033 (0.005) | <0.001 | −0.033 (0.005) | <0.001 |
| rs28470352 | ||||
| TT (reference) | – | – | – | – |
| TA | −0.003 (0.040) | 0.946 | – | – |
| AA | −0.061 (0.065) | 0.353 | – | – |
| rs2230037 | ||||
| GG (reference) | – | – | – | – |
| GA | 0.007 (0.010) | 0.467 | 0.006 (0.010) | 0.506 |
| AA | 0.020 (0.010) | 0.041 | 0.018 (0.009) | 0.051 |
| rs1050829 | ||||
| TT (reference) | – | – | – | – |
| CT | −0.012 (0.040) | 0.768 | −0.016 (0.010) | 0.117 |
| CC | 0.051 (0.065) | 0.439 | −0.011 (0.009) | 0.208 |