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. 2021 Apr 9;9:569045. doi: 10.3389/fbioe.2021.569045

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Copyright © 2021 Strasser, Farrell, Ho, Scheffler, Cook, Pankert, Mowlds, Viner, Karger and Bones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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For bioprocess monitoring of CHO DP-12 batch cultures, viable cell density was determined daily using the trypan blue exclusion method. Additionally, lactate concentration and IgG production were analyzed using a Cedex Bio Analyzer (Roche). Shown are results after shifting (A) temperature, (B) pH, or (C) DO concentration. Red shows an increase whereas blue indicates a reduction of the correlating parameter. Results obtained from standard conditions are shown in gray (mean ± standard deviation, n = 3). Dashed line indicates time point (day 5) for alterations of process parameters.