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. 2021 Feb 28;204(2):267–282. doi: 10.1111/cei.13581

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Fig. 5 — (a) Molecular pathways of human umbilical endothelial cells (HUVECs) stimulated with neutrophil‐derived extracellular vesicles (EVs); (b) miRNA/mRNA/protein network in endothelial cells stimulated with the neutrophil‐derived extracellular vesicles. Circles = proteins released from the cells stimulated with EVs; rectangles = predicted miRNA/mRNA interactions in HUVECs stimulated with EVs. Left side of the panel: down‐regulated mRNA and up‐regulated miRNA; right side of the panel: down‐regulated miRNA and up‐regulated mRNA/proteins. Interaction network is based on the results of miRNA/mRNA/protein profiling of EVs stimulated HUVECs and were constructed using data bases: miRPathDB 2.0, miRTargetLink Human and miRandola 2017 [22, 25, 26].