Table 2. Factors associated with reduced PrEP uptake among youth in the United States.

Patient-level barriers

Lack of awareness

Lack of access to healthcare

Stigma

Poverty

Concerns about side effects or drug-drug interactions

Concerns about proper storage of medication

Lack of social support

Low perceived risk of HIV infection

Burden of daily-dosing

Burden of frequent clinic visits and lab testing

Structural barriers

Limited health insurance

Insufficient youth-friendly services

Stigma

Structural racism

Provider-level barriers

Lack of comfort prescribing to minors

The purview paradox

PrEP, pre-exposure prophylaxis.