FIGURE 3.

Chemical structure, IC50 values and representative traces of transporter-mediated currents for mephedrone and the selected metabolites. All the metabolites showing an IC50 < 30 µM in one of the two transporters were tested for their ability to elicit transporter-mediated currents. For each of the selected metabolites, representative traces for DAT and SERT are shown below the respective chemical structure. DAT-mediated currents are highlighted by a light-red background, while SERT-mediated currents are highlighted with a light-blue background. The different enantiomers of a specific metabolite are in the same color. All the compounds, including mephedrone, are applied at 30 µM.