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. 2021 Apr 9;9:647496. doi: 10.3389/fcell.2021.647496

FIGURE 1.

FIGURE 1

Prednisolone suppressedpro-inflammatory cytokine production by human endometrial stromalfibroblast (hESF). Prednisolone treatment: (A) inhibitedhESF pro-inflammatory cytokine [interleukin (IL) 6, and IL18] gene expression, but had no effect on IL10 gene expression, paired t-test, n = 3-4/group; (B) had no effect on hESF glucocorticoid receptor (GR) gene expression, paired t-test, n = 4/group; (C) had no effect on classic decidualization makers prolactin (PRL) or insulin-like growth factor binding protein (IGFBP)1 expression; (D) had no effect on decidualization genes bone morphogenic protein (BMP)2, BMP7, homeobox A (HOXA)10 or inhibinβA (INHBA), but inhibited IL11, leukemia inhibitory factor (LIF) and LIF receptor (LIFR) gene expression, paired t-test, n = 4/group. Data presented as mean ± SEM; *P < 0.05.