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. 2021 Apr 9;12:646477. doi: 10.3389/fphar.2021.646477

FIGURE 3.

FIGURE 3

(A,B): Effects of intrathecal injection of DMSO (vehicle) or different doses of Nrf2 agonist tBHQ on mechanical allodynia and thermal hyperalgesia in SNI rats. (C–E): Effects of intrathecal injection of DMSO or different doses of Nrf2 agonist tBHQ on expression of Nrf2 and its downstream target NQO1 in the whole tissue lysates of the spinal cord in SNI rats. (F,G): Effects of intrathecal injection of DMSO and different doses of Nrf2 agonist tBHQ on expression of Nrf2 in the nuclear fractions of the spinal cord in SNI rats. Sham rats without treatment served as control. Values are expressed as mean ± SE (n = 4 for each group). *p < 0.05 vs sham or baseline (day 0); # p < 0.05 vs SNI or DMSO.