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. 2021 Jan 28;11(3):jkab022. doi: 10.1093/g3journal/jkab022

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© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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The let-7 SM+SUP sites in the 3′ UTR region of lin-41 are highly conserved in Caenorhabditis species that contain let-7. Sequence alignment of the bulge-SM+SUP site (A) and the GU-SM+SUP (B) in the 3’ UTR region of lin-41 in Caenorhabditis species containing let-7. Shown at the bottom of each panel is the respective consensus sequence predicted hybridization with let-7 microRNA. Watson–Crick base pairing is shown with a solid line between the paired bases. The G-U base pair in the seed is shown with an asterisk between the paired bases.