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. 2021 Apr 9;9:647130. doi: 10.3389/fcell.2021.647130

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Copyright © 2021 Zhao, Guan, Meng, Wang, Wu, Chen, Hu, Zhu, Zhang, Mu, Chen, Sun, Wu, Wang, Zhou, Dong, Zeng, Liu, Li, Du, Kuang, Sang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The location and conservation analysis of altered residues in CDC20. (A) The distribution of mutations in the CDC20 gene and protein structure. The mutations described in our previous study (Zhao et al., 2020b) are marked in purple, the novel mutations identified in this study are marked in green, and mutation c.965G > A (p.Arg322Gln), which was found in both this study and our previous study, is marked in orange. (B) Conservation of the altered residues is indicated by the alignment of six mammalian species.