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. 2021 Apr 9;9:647130. doi: 10.3389/fcell.2021.647130

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Copyright © 2021 Zhao, Guan, Meng, Wang, Wu, Chen, Hu, Zhu, Zhang, Mu, Chen, Sun, Wu, Wang, Zhou, Dong, Zeng, Liu, Li, Du, Kuang, Sang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the mutations on kinetochore localization in mouse oocytes and the CDC20 rescue ability in Cdc20 knockdown mouse oocytes. (A) Kinetochore localization of wild type and mutant FLAG-tagged CDC20 in mouse MI oocytes. Images were captured by confocal microscopy (Leica). Hoechst and Crest were used to label the DNA and kinetochores, respectively. (B) The effects of the mutations on the rescue of Cdc20 knockdown mouse oocytes. The number of oocytes with PB1 extrusion and the total number of oocytes used are listed at the top of the column. Significance was compared between the no injection group and the siCdc20 group, the siCdc20 coupled with wild-type CDC20 cRNA group, and the siCdc20 coupled with mutant CDC20 cRNA groups. Two independent experiments were performed followed the chi-square test. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant.