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. 2021 Apr 9;12:663110. doi: 10.3389/fgene.2021.663110

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Copyright © 2021 Gao, Xu, Li, Hu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of miR-93-5p could reduce SK-MEL-28 cells' invasive ability through UBC. (A) The miR-93-5p and UBC expression data of 449 melanoma patients from ENCORI. We observed the inverse correlation with statistical significance between miR-93-5p and UBC mRNA. (B) Diagram of UBC 3'UTR including 1 putative conserved target sites for miR-93-5p, recognized through making use of the TargetScan database. (C) Results of luciferase reporter experiments in SK-MEL-28 cells, with co-transfection of wt or mt 3'UTR and miR mimic, as shown. (D) The protein expression of UBC in SK-MEL-28 cells transfected with miR-93-5p. (E) SK-MEL-28 transfected with miR-93-5p inhibitor invaded less vs. control cancer cells, and the anti-invasive effect by miR-93-5p inhibitor was reduced when the expression of UBC was decreased by its siRNA. **P < 0.01 miR-93-5p inhibitor vs. control, ^##P < 0.01 miR-93-5p inhibitor vs. miR-93-5p inhibitor+siUBC.