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MKL1 deletion in macrophages ameliorates pressure overload induced cardiac inflammation and fibrosis in mice. MFCKO mice and WT mice were subjected to the TAC procedure. (A–C) Pro-inflammatory genes were measured by qPCR. (D) CD45 staining. (E–G) Pro-fibrogenic genes were measured by qPCR. (H) Picrosirius red staining. (I) Masson’s trichrome staining. N = 5 mice for each group. Data represent mean ± SD. *p < 0.05, two-tailed t-test.
