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. 2021 Apr 9;9:583492. doi: 10.3389/fcell.2021.583492

FIGURE 4.

FIGURE 4

MKL1 regulates miR-155 expression in macrophages. (A) MFCKO mice and WT mice were subjected to the TAC procedure. miR-155 levels were examined by qPCR. N = 5 mice for each group. Data represent mean ± SD. *p < 0.05, two-tailed t-test. (B) RAW cells were transfected with MKL1 expression construct or an empty vector (EV) followed by treatment with endothelin. miR-155 levels were examined by qPCR. (C) RAW cells were transfected with siRNA targeting MKL1 or SCR followed by treatment with endothelin. miR-155 levels were examined by qPCR. (D) RAW cells were treated with endothelin and CCG-1423. miR-155 levels were examined by qPCR. (E) BMDMs isolated from WT and MFCKO were treated with endothelin. miR-155 levels were examined by qPCR. Data represent mean ± SD. *p < 0.05, One-way ANOVA with post hoc Scheffe test.