Fig. 3.
Features of the MR-histology validation literature. [A] Sample size distribution of the included papers (median = 13 subjects). [B] The most frequently used histology techniques used in the articles are shown in decreasing order. [C] Due to lack of commonly agreed reporting standards, some relevant information may be missing from validation studies. The most commonly missing pieces of information on methods are reported here. [D] Pie chart of species and field strength used in each study. [E] Frequency of different statistical measures used for the validation analysis. [F] MR markers most commonly used in the literature, subdivided based on MR technique they are based on. The graphs show that DWI, MT and relaxometry are by far the most commonly explored techniques in validation studies. Within studies using DWI, tensor-based measures are predominant.