Figure 10.

Detection of IR775c-conjugated gold nanorods-labeled cell viability in vivo. (a) Ratiometric imaging of stem cell viability in vivo created with photoacoustic images of day 0, 1, 3, 5, 7, and 10 at 795 and 920 nm. (b) Photoacoustic spectra changes over time; the IR775c peak (790 nm) gradually decreases over time, while the gold nanorods peak (910 nm) was stable. (c) Quantification of relative viability showed 92% viable cells on day 0 to 5% viable by day 10, which is similar to in vitro measurements of stem cells incubated with doxorubicin. **** p < 0.0001 compared to all days. # p <.05 compared to day 7 and 10. & p < 0.05 compared to day 10. Adapted with permission from [¹⁷¹]. Copyright (2019) American Chemical Society.