Figure 11.

Dynamic photoacoustic signal and bacterial killing effect of silver coated gold nanoparticles. (a) Schematic of the photoacoustic signal (PA) changes associated with the silver coating and releasing. Representative TEM images show gold nanorods, silver coated gold nanorods, and etched silver coated gold nanorods. (b) Ultrasound and photoacoustic images of subcutaneously injected silver-gold hybrid nanoparticles with and without the addition of etchant, which triggered the release of silver ions. The PAI signal was significantly higher when the silver ions were released. (c) Representative photographs of the MRSA-infected wound from mice in three different treatment groups. The hybrid nanoparticles with released silver ions (Au/Ag (Etch)) showed a strong bactericidal efficacy in vivo. Figures reprinted with permission from [¹⁷³]. Copyright (2018) American Chemical Society.