. Author manuscript; available in PMC: 2022 Jan 21.

Published in final edited form as: Biomater Sci. 2020 Oct 15;9(2):367–390. doi: 10.1039/d0bm01063d

Table 2.

OCT contrast mechanisms associated with gold nanoparticles with different shape and their applications in ophthalmic molecular imaging.

Type of particles	OCT contrast mechanism	Applications in ophthalmic molecular imaging
Gold nanorods	Backscattering enhancement ^{95, 96, 97}	Imaging ocular surface squamous neoplasia ⁹⁵ Cornea imaging ⁹⁶ Tracking cells in retinal vessels ⁹⁷
	Spectral contrast ^{99,100, 101,102, 103, 104}	--
	Signal-modulation (PT-OCT) ^{112, 113}	Imaging choroidal neovascularization ^{112, 113}
	Dark contrast (Depolarization) ¹¹⁴	--
Gold nanoshells	Backscattering enhancement ^{86–90, 91, 92}	--
Gold nanodisks	Backscattering enhancement ^{28, 98}	Therapeutic gold nanoparticle tracking ²⁸
Gold nanoprisms	Backscattering enhancement ¹⁰	--
Gold nanoprisms	Biosensing ^{108, 109, 110}	Monitoring ozone penetration into cornea ¹⁰⁸
Gold nanobipyramds	Spectral contrast ^73,105	--