Table 1.
Patient baseline characteristics and demographics
| Variable | Total (N = 9901) | Age ≥ 65 y (N = 5256) | Age < 65 y (N = 4645) | P |
|---|---|---|---|---|
| Age, y (mean ± SD) | 66.2 ± 6.5 | 71.0 ± 4.6 | 60.7 ± 3.2 | < .001 |
| Female (n, %) | 4589 (46.3) | 2453 (46.7) | 2136 (46.0) | .495 |
| White (n, %) | 7498 (75.7) | 3989 (75.9) | 3509 (75.5) | .685 |
| Duration of diabetes, y (mean ± SD) | 10.5 ± 7.2 | 11.5 ± 7.7 | 9.4 ± 6.5 | < .001 |
| HbA1c, % (mean ± SD) | 7.3 ± 1.1 | 7.3 ± 1.0 | 7.4 ± 1.1 | < .001 |
| Weight, kg (mean ± SD) | 88.7 ± 18.5 | 86.1 ± 17.4 | 91.6 ± 19.2 | < .001 |
| BMI, kg/m2 (mean ± SD) | 32.3 ± 5.7 | 31.6 ± 5.4 | 33.1 ± 6.0 | < .001 |
| Prior CVD (≥ 1 of the following), n (%) | 3114 (31.5) | 1598 (30.4) | 1516 (32.6) | .006 |
| Prior myocardial infarction | 1602 (16.2) | 797 (15.2) | 805 (17.3) | .011 |
| Prior ischemic stroke | 528 (5.3) | 262 (5.0) | 266 (5.7) | .101 |
| Prior unstable angina | 587 (5.9) | 291 (5.5) | 296 (6.4) | .210 |
| Prior revascularizationa | 1787 (18.0) | 966 (18.4) | 821 (17.7) | .363 |
| Prior hospitalization for ischemia-related eventsb | 1193 (12.0) | 612 (11.6) | 581 (12.5) | .086 |
| Prior documented MI | 922 (9.3) | 468 (8.9) | 454 (9.8) | .007 |
| Prior hypertension, n (%) | 9224 (93.2) | 4960 (94.4) | 4264 (91.8) | < .001 |
| Prior heart failure, n (%) | 853 (8.6) | 425 (8.1) | 428 (9.2) | .081 |
Abbreviations: BMI, body mass index; CVD, cardiovascular disease; HbA1c, glycated hemoglobin A1c, MI, myocardial ischemia.
a Coronary, carotid, or peripheral.
b Unstable angina or MI on imaging, or need for percutaneous coronary intervention. Continuous variables were compared using t test if variables satisfied normality, otherwise the Wilcoxon rank sum test was performed. Categorical variables were compared using Pearson chi-square test if the expected counts were 5 or greater in at least 80% of the cells, otherwise the Fisher exact test was performed. For categorical variables, missing or unknown values were counted as a separate category.