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. 2021 Apr 23;21:451. doi: 10.1186/s12885-021-08150-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — EGFR family expression was correlated with macrophage polarization in glioma. Markers include CD86 and CSF1R of monocytes; CCL2, CD68, and IL10 of TAMs (tumor-associated macrophages); NOS2, IRF5, and PTGS2 of M1 macrophages; and CD163, VSIG4, and MS4A4A of M2 macrophages in glioma (n = 153). a-d Scatterplots of correlations between EGFR expression and gene markers of monocytes, TAMs, and M1 and M2 macrophages. e-h Scatterplots of correlations between ERBB2 expression and gene markers of monocytes, TAMs, and M1 and M2 macrophages. i-l Scatterplots of correlations between ERBB3 expression and gene markers of monocytes, TAMs, and M1 and M2 macrophages. m-p Scatterplots of correlations between ERBB4 expression and gene markers of monocytes, TAMs, and M1 and M2 macrophages