Table 3.
GO and KEGG enrichment analysis of the EGFR family and their 20 interactors
| Category | Terms | Description | Count | FDR |
|---|---|---|---|---|
| BP | GO:0038128 | ERBB2 signaling pathway | 12 | 2.95E-21 |
| BP | GO:2000145 | regulation of cell motility | 10 | 2.63E-17 |
| BP | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 10 | 6.11E-13 |
| BP | GO:0046854 | phosphatidylinositol phosphorylation | 10 | 3.83E-12 |
| BP | GO:0048015 | phosphatidylinositol-mediated signaling | 10 | 1.18E-11 |
| BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 10 | 3.45E-10 |
| BP | GO:0007173 | epidermal growth factor receptor signaling pathway | 8 | 1.01E-09 |
| BP | GO:0000165 | MAPK cascade | 10 | 4.45E-08 |
| BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 8 | 5.02E-08 |
| BP | GO:0043547 | positive regulation of GTPase activity | 11 | 1.83E-06 |
| BP | GO:0042060 | wound healing | 6 | 9.38E-05 |
| BP | GO:0008284 | positive regulation of cell proliferation | 9 | 1.55E-04 |
| MF | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 10 | 5.51E-14 |
| MF | GO:0004713 | protein tyrosine kinase activity | 11 | 7.11E-13 |
| MF | GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 10 | 1.84E-11 |
| MF | GO:0005154 | epidermal growth factor receptor binding | 6 | 5.20E-07 |
| MF | GO:0046875 | ephrin receptor binding | 5 | 4.08E-05 |
| MF | GO:0004716 | receptor signaling protein tyrosine kinase activity | 4 | 2.80E-04 |
| KEGG | hsa04012 | ERBB signaling pathway | 18 | 2.00E-29 |
| KEGG | hsa05214 | Glioma | 8 | 1.53E-07 |
| KEGG | hsa05223 | Non-small cell lung cancer | 7 | 4.12E-06 |
| KEGG | hsa04722 | Neurotrophin signaling pathway | 8 | 1.21E-05 |
| KEGG | hsa05220 | Chronic myeloid leukemia | 7 | 1.93E-05 |
| KEGG | hsa04014 | Ras signaling pathway | 9 | 4.27E-05 |
| KEGG | hsa05206 | MicroRNAs in cancer | 9 | 2.66E-04 |
| KEGG | hsa05205 | Proteoglycans in cancer | 8 | 4.15E-04 |
| KEGG | hsa04510 | Focal adhesion | 8 | 5.07E-04 |
| KEGG | hsa05215 | Prostate cancer | 6 | 0.002482 |
| KEGG | hsa05200 | Pathways in cancer | 9 | 0.003013 |
| KEGG | hsa04915 | Estrogen signaling pathway | 6 | 0.004453 |
| KEGG | hsa05213 | Endometrial cancer | 5 | 0.00888 |
BP, Biological processes; MF, molecular functions; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, gene ontology; FDR, false discovery rates