Table 1.
Baseline and intra-operative characteristics in patients with and without surgery-related loss of muscle quantity or quality
| Factors | Total n = 128 (100%) | Muscle quantity loss n = 67 (52%) | No muscle quantity loss n = 61 (48%) | P-value | Muscle quality loss n = 83 (65%) | No muscle quality loss n = 45 (35%) | P-value |
|---|---|---|---|---|---|---|---|
| Age, mean (SD), years | 65.5 (8.7) | 65.4 (7.7) | 65.6 (9.6) | 0.896 | 66.9 (7.8) | 62.7 (9.6) | 0.008 |
| Sex, male | 89 (69.5%) | 50 (74.6%) | 39 (63.9%) | 0.249 | 62 (74.7%) | 27 (60.0%) | 0.085 |
| BMI, mean (SD), kg/m2 | 25.6 (3.1) | 25.9 (3.0) | 25.5 (3.2) | 0.473 | 25.8 (3.1) | 25.5 (3.1) | 0.677 |
| CEAa, median (IQR), μg/L | 6.3 (2.8–22.3) | 5.7 (2.4–19.0) | 8.0 (3.2–33) | 0.146 | 6.5 (2.9–35.0) | 5.6 (2.6–15.0) | 0.322 |
| ASA score | |||||||
| I | 14 (10.9%) | 7 (10.4%) | 7 (11.5%) | 0.580 | 6 (7.2%) | 8 (17.8%) | 0.184 |
| II | 107 (83.6%) | 55 (82.1%) | 52 (85.2%) | 72 (86.7%) | 35 (77.8%) | ||
| III | 7 (5.5%) | 5 (7.5%) | 2 (3.3%) | 5 (6.0%) | 2 (4.4%) | ||
| Comorbidities | |||||||
| Diabetes | 7 (5.5%) | 5 (7.5%) | 2 (3.3%) | 0.298 | 5 (6%) | 2 (4.4%) | 0.707 |
| Chronic obstructive pulmonary disease | 6 (4.7%) | 5 (7.5%) | 1 (1.6%) | 0.120 | 4 (4.8%) | 2 (4.4%) | 0.924 |
| Charlson Comorbidity Index | |||||||
| 0 | 103 (80.5%) | 53 (79.1%) | 50 (82%) | 0.786 | 66 (79.5%) | 37 (82.2%) | 0.867 |
| I | 19 (14.8%) | 10 (14.9%) | 9 (14.8%) | 13 (15.7%) | 6 (13.3%) | ||
| II | 5 (3.9%) | 3 (4.5%) | 2 (3.2%) | 3 (3.6%) | 2 (4.4%) | ||
| III | 1 (0.8%) | 1 (1.5%) | 0 (0.0%) | 1 (1.2%) | 0 (0.0%) | ||
| CT scan | |||||||
| Time-frame pre-scan and OK, mean (SD), days | 28.2 (9.6) | 28.4 (9.9) | 27.9 (9.2) | 0.755 | 27.1 (9.5) | 30.1 (9.5) | 0.091 |
| Time-frame OK and post-scan, mean (SD), days | 7.1 (3.0) | 7.4 (3.4) | 6.6 (2.5) | 0.130 | 6.7 (2.7) | 7.6 (3.5) | 0.175 |
| Operation type | |||||||
| Laparoscopic/open | 15 (11,7%)/113 (88,3%) | 6 (9.0%)/61 (91%) | 9 (14.8%)/52 (85.2%) | 0.308 | 4 (4,8%)/79 (95.2%) | 11 (24,4%)/34 (75,6%) | 0.001 |
| Minor/major | 74 (57.8%)/54 (42.2%) | 37 (55.2%)/30 (44.8%) | 37 (60.7%)/24 (39.3%) | 0.534 | 47 (56.6%)/36 (43.3%) | 27 (60.0%)/18 (40%) | 0.712 |
| Resection/resection + RFA | 104 (81.3%)/24 (18.8%) | 49 (73.1%)/18 (26.9%) | 55 (90.2%)/6 (9.8%) | 0.014 | 65 (78.3%)/18 (21.7%) | 39 (86.7%)/6 (13.3%) | 0.248 |
| Operation parameters | |||||||
| Blood loss, median (IQR), mL | 400 (200–750) | 400 (187–700) | 400 (200–800) | 0.728 | 500 (200–763) | 300 (100–625) | 0.062 |
| Operation time, mean (SD), min | 134.2 (61.6) | 130.2 (58.9) | 138.8 (64.6) | 0.434 | 142.7 (65) | 118.1 (51.1) | 0.035 |
SD standard deviation, IQR interquartile range, BMI body mass index, CEA carcinoembryonic antigen, ASA American Society of Anaesthesiologists, CT computer tomography, RFA radiofrequency ablation
The values given are numbers of patients unless indicated otherwise. Bold variables were considered statistically significant (P < 0.05)
a28 patients missing