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Overview of folate, vitamin B6, and vitamin B12 in homocysteine metabolism. Homocysteine is reconverted to methionine by receiving a methyl group from 5-methyltetrahydrofolate, the active form of folate, or betaine in the remethylation pathway. Irreversible removal of homocysteine occurs through the transsulphuration pathway where homocysteine condenses with serine to form cystathionine
