Table 1.
Information on outcome data sources
| Data source | Cardiovascular disease | Population | Cases | Controls | Covariates adjusted in GWAS |
|---|---|---|---|---|---|
| Consortium (Nielsen et al.) | Atrial fibrillation | European | 60,620 | 970,216 | Birth year, sex, genotype batch, and one to four principal components |
| CARDIoGRAMplusC4D+UKBB | Coronary artery disease | Mixed | 122,733 | 424,528 | Not reported |
| HERMES consortium | Heart failure | European | 47,309 | 930,014 | Age and sex, and principal components in individual studies where applicable |
| MEGASTROKE consortium | Stroke | 40,585 | 406,111 | Age and sex | |
| Ischemic stroke | 34,217 | NA | |||
| ISGC | Intracerebral hemorrhage | European | 3223 | 3725 | Age, sex, and principal components |
| Consortium (Bakker et al.) | Subarachnoid hemorrhage | European | 7495 | 71,934 | Not reported |
| The UK Biobank study (UKBB) | Aortic aneurysm | European | 2261 | 365,300 | Age, sex, and ten genetic principal components |
| Aortic valve stenosis | 3528 | 364,033 | |||
| Stroke | 12,036 | 355,525 | |||
| Intracerebral hemorrhage | 1504 | 366,057 | |||
| Ischemic stroke | 6566 | 360,995 | |||
| Transient ischemic attack | 4813 | 362,748 | |||
| Venous thromboembolism | 16,412 | 351,149 | |||
| Peripheral vessel disease | 4593 | 362,968 | |||
| The FinnGen consortium | Aortic aneurysm | European | 1919 | 167,843 | Age, sex, the first ten genetic principal components, and genotyping batch |
| Atrial fibrillation | 17,325 | 97,214 | |||
| Coronary artery disease | 16,631 | 160,268 | |||
| Heart failure | 9576 | 159,286 | |||
| Stroke | 14,171 | 133,027 | |||
| Intracerebral hemorrhage | 1224 | 163,533 | |||
| Subarachnoid hemorrhage | 1019 | 163,508 | |||
| Ischemic stroke | 8046 | 164,286 | |||
| Transient ischemic attack | 6729 | 164,286 | |||
| Venous thromboembolism | 6913 | 169,986 | |||
| Peripheral vessel disease | 5323 | 167,843 |
CARDIoGRAMplusC4D Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics, GWAS genome-wide association study, HERMES Heart Failure Molecular Epidemiology for Therapeutic Targets, ISGC International Stroke Genetic Consortium, NA not available. The UK Biobank was included in Consortium (Nielsen et al.), HERMES consortium, ISGC, and Consortium (Bakker et al.)