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. 2021 Apr 22;22:211. doi: 10.1186/s12859-021-04136-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Evaluation of the influence of sensitive genes on unsupervised clustering results. a The ground-truth labels with cell-type annotation of the first sample in PbmcBench PBMC1 data set; b ECA and ECP values in a series of resolution (0.6, 0.9, 1,1.2, 1.5, 1.8, 2) including and removing sensitive genes. Arrows aimed from the group keeping the sensitive genes to the group discarding the sensitive genes. The paired points in two groups with the same number of clusters were marked by red arrows, the paired points in two groups with different number of clusters were marked by black arrows; c The first-time unsupervised clustering result (resolution = 0.6); d The unsupervised clustering result (resolution = 0.6) removing sensitive genes