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. 2021 Apr 23;9:74. doi: 10.1186/s40478-021-01178-7

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© The Author(s) 2021, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Basement membrane structural change in mTBI mice. a–b Representative confocal microscope images (a) and quantification (b) showing upregulation of collagen IV in mTBI-impacted ipsilateral cortical area 3 days after mTBI compare to contralateral side. Scale bar = 50 µm. c Representative confocal microscope images showing differential laminin α2 and α4 levels in mTBI-impacted ipsilateral cortical area and contralateral side 3 days after mTBI. d Quantification of α2 and α4 ratio based on fluorescent intensities in mTBI-impacted ipsilateral cortical area compare to contralateral side. Scale bar = 30 µm. n = 6 mice per group. Mean ± SD in b, d; **, P < 0.01; ***, P < 0.001; NS, non-significant (P > 0.05) by Student’s t-test